Students model ABO and Rh blood types through notes, virtual blood typing, and an interactive game.
This digital biology lesson introduces students to the science of blood typing by connecting blood components, antigen structure, and medical application. Students work through visual models and structured practice to understand how blood types are determined and why compatibility matters.
Rather than memorizing charts, students build understanding by modeling blood cells, interpreting test results, and applying compatibility rules.
Students complete a sequence of scaffolded tasks that require them to:
• identify the major components of blood and their functions
• model ABO blood types by placing antigens on red blood cells
• determine universal donors and receivers
• analyze a short video on the history and global distribution of blood types
• model Rh positive and Rh negative blood types
• interpret blood typing test results
• perform virtual blood typing using simulated samples
• determine which blood types can safely donate to others
• analyze U.S. blood type frequency data
An interactive review game is included to reinforce learning.
• Blood components and their functions
• ABO blood group system
• Antigens and antibodies
• Rh factor
• Blood compatibility
• Medical relevance of blood typing
• Data interpretation
• Makes abstract antigen concepts visual
• Builds understanding through modeling
• Connects biology to real medical applications
• Includes multiple representations of blood typing
• Supports visual and analytical learners
• Works for guided instruction or independent practice
• Minimal prep required
This resource is a digital interactive lesson (Google Slides compatible) with built-in student tasks.
Includes:
✔ Student lesson slides
✔ Teacher answer key
✔ Exit ticket
✔ Interactive modeling activities
• Middle school life science
• High school biology
• Units on the circulatory system
• Genetics and inheritance connections
• Lessons on medical biology
• Sub plans or digital learning days
To preview this product, click here.
Daily slide + literacy - based exit ticket included with purchase
HS-LS1-2: Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms. (connection: blood as a system of cells with specialized functions—red blood cells, white blood cells, platelets, plasma)
HS-LS1-3: Plan and conduct an investigation to provide evidence that feedback mechanisms maintain homeostasis. (connection: blood compatibility, immune response, transfusion reactions)
Science & Engineering Practices: Developing and using models; Planning and carrying out investigations; Asking questions and defining problems.
Crosscutting Concepts: Structure and function; Cause and effect; Systems and system models.
Common Core Alignment
CCSS.ELA-LITERACY.RST.9-10.4 / RST.11-12.4: Determine the meaning of domain-specific terms (antigen, antibody, Rh factor).
CCSS.ELA-LITERACY.RST.9-10.7 / RST.11-12.7: Integrate quantitative information (blood compatibility charts) with written explanations.
CCSS.ELA-LITERACY.WHST.9-12.2: Write explanatory texts that describe inheritance and immune response in blood typing.
Students model ABO and Rh blood types through notes, virtual blood typing, and an interactive game.
This digital biology lesson introduces students to the science of blood typing by connecting blood components, antigen structure, and medical application. Students work through visual models and structured practice to understand how blood types are determined and why compatibility matters.
Rather than memorizing charts, students build understanding by modeling blood cells, interpreting test results, and applying compatibility rules.
Students complete a sequence of scaffolded tasks that require them to:
• identify the major components of blood and their functions
• model ABO blood types by placing antigens on red blood cells
• determine universal donors and receivers
• analyze a short video on the history and global distribution of blood types
• model Rh positive and Rh negative blood types
• interpret blood typing test results
• perform virtual blood typing using simulated samples
• determine which blood types can safely donate to others
• analyze U.S. blood type frequency data
An interactive review game is included to reinforce learning.
• Blood components and their functions
• ABO blood group system
• Antigens and antibodies
• Rh factor
• Blood compatibility
• Medical relevance of blood typing
• Data interpretation
• Makes abstract antigen concepts visual
• Builds understanding through modeling
• Connects biology to real medical applications
• Includes multiple representations of blood typing
• Supports visual and analytical learners
• Works for guided instruction or independent practice
• Minimal prep required
This resource is a digital interactive lesson (Google Slides compatible) with built-in student tasks.
Includes:
✔ Student lesson slides
✔ Teacher answer key
✔ Exit ticket
✔ Interactive modeling activities
• Middle school life science
• High school biology
• Units on the circulatory system
• Genetics and inheritance connections
• Lessons on medical biology
• Sub plans or digital learning days
To preview this product, click here.
Daily slide + literacy - based exit ticket included with purchase
HS-LS1-2: Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms. (connection: blood as a system of cells with specialized functions—red blood cells, white blood cells, platelets, plasma)
HS-LS1-3: Plan and conduct an investigation to provide evidence that feedback mechanisms maintain homeostasis. (connection: blood compatibility, immune response, transfusion reactions)
Science & Engineering Practices: Developing and using models; Planning and carrying out investigations; Asking questions and defining problems.
Crosscutting Concepts: Structure and function; Cause and effect; Systems and system models.
Common Core Alignment
CCSS.ELA-LITERACY.RST.9-10.4 / RST.11-12.4: Determine the meaning of domain-specific terms (antigen, antibody, Rh factor).
CCSS.ELA-LITERACY.RST.9-10.7 / RST.11-12.7: Integrate quantitative information (blood compatibility charts) with written explanations.
CCSS.ELA-LITERACY.WHST.9-12.2: Write explanatory texts that describe inheritance and immune response in blood typing.
