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How do Mutations Affect Protein Synthesis?
Engage Your Students in a Deep Exploration of Genetic Diseases with this Interactive Google Slides Lesson!
Advanced Genetic Studies: Designed for students with prior knowledge of DNA mutations and protein synthesis, this lesson dives into the intricate realm of genetic diseases. It provides a visually captivating and intellectually stimulating experience that reinforces key genetics concepts.
In-Depth Disease Analysis: The lesson centers around four well known genetic diseases—Tay-Sachs, Sickle Cell Anemia, Hemophilia, and Cystic Fibrosis. Students embark on a journey of understanding by comparing the pertinent proteins in both healthy and afflicted individuals. Through careful examination, they discern which protein is non-functional or absent.
Unraveling Genetic Mutations: With their newfound insights, students delve into the DNA strands of the individuals. By analyzing the mutations in relation to the observed affliction, they deduce the specific mutation type and its impact. The lesson ensures that the assigned mutations align with real-world occurrences.
Connecting Structure to Symptoms: The final segment challenges students to correlate the altered protein's structure with the symptoms manifested in each respective genetic disease. This critical thinking exercise deepens comprehension and fosters a holistic understanding of the interplay between genetics and health outcomes.
Challenging Yet Engaging: This visually appealing and interactive lesson strikes a balance between complexity and engagement. It serves as a powerful tool to solidify genetics concepts, leaving a lasting impact on students' grasp of advanced genetic studies.
Elevate Genetic Understanding: Download this comprehensive lesson now to provide your students with a dynamic opportunity to explore genetic diseases, unravel mutations, and connect genetic structure to real-world health outcomes. Watch as their understanding of advanced genetic concepts reaches new heights!
Grade & Course Recommendation:
Middle School: Grade 8 Advanced Life Science, during heredity or molecular biology units.
High School: Grade 9–10 Biology, as a capstone for gene expression and mutations.
Cross-Curricular Connections:
Math Integration: Students interpret codon charts and calculate ratios of correct vs. mutated sequences.
ELA Integration: Students construct written explanations of cause and effect in genetic processes.
Health Science Integration: Ties to disorders resulting from frame-shift or point mutations.
Daily slide + literacy - based exit ticket included with purchase
Join the Lesson Laboratory and Teach for Tomorrow!
NGSS (Next Generation Science Standards)
High School NGSS Alignment
HS-LS1-1: Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.
Connection: Students analyze examples of how mutations alter DNA sequences and disrupt protein structure and function.HS-LS3-1: Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.
Connection: Students link specific mutations to phenotypic changes such as cystic fibrosis, Tay-Sachs disease, or sickle cell anemia.HS-LS3-2: Make and defend a claim based on evidence that inheritable genetic variations may result from new genetic combinations through meiosis, errors during replication, and/or mutations caused by environmental factors.
Connection: Students examine how different types of mutations—point, frameshift, insertion, deletion, and inversion—produce variations in proteins and traits.
Science & Engineering Practices:
Analyzing and interpreting data
Constructing explanations and designing solutions
Obtaining, evaluating, and communicating information
Crosscutting Concepts:
Structure and function
Cause and effect
Systems and system models
Common Core Standards
Grades 9–12:
CCSS.ELA-LITERACY.RST.9-10.3 / RST.11-12.3: Follow precisely a complex multistep procedure when carrying out experiments, taking measurements, or performing technical tasks. (Students interpret DNA-to-protein examples and mutation mechanisms step-by-step.)
CCSS.ELA-LITERACY.RST.9-10.4 / RST.11-12.4: Determine the meaning of domain-specific words and phrases (e.g., frameshift, codon, inversion, translation).
CCSS.ELA-LITERACY.RST.9-10.7 / RST.11-12.7: Integrate quantitative or technical information expressed in words with a version expressed visually (DNA sequences, codon charts, diagrams).
CCSS.ELA-LITERACY.WHST.9-10.2: Write informative/explanatory texts, including scientific analyses and summaries. (Students explain how mutations lead to specific phenotypes.)
Engage Your Students in a Deep Exploration of Genetic Diseases with this Interactive Google Slides Lesson!
Advanced Genetic Studies: Designed for students with prior knowledge of DNA mutations and protein synthesis, this lesson dives into the intricate realm of genetic diseases. It provides a visually captivating and intellectually stimulating experience that reinforces key genetics concepts.
In-Depth Disease Analysis: The lesson centers around four well known genetic diseases—Tay-Sachs, Sickle Cell Anemia, Hemophilia, and Cystic Fibrosis. Students embark on a journey of understanding by comparing the pertinent proteins in both healthy and afflicted individuals. Through careful examination, they discern which protein is non-functional or absent.
Unraveling Genetic Mutations: With their newfound insights, students delve into the DNA strands of the individuals. By analyzing the mutations in relation to the observed affliction, they deduce the specific mutation type and its impact. The lesson ensures that the assigned mutations align with real-world occurrences.
Connecting Structure to Symptoms: The final segment challenges students to correlate the altered protein's structure with the symptoms manifested in each respective genetic disease. This critical thinking exercise deepens comprehension and fosters a holistic understanding of the interplay between genetics and health outcomes.
Challenging Yet Engaging: This visually appealing and interactive lesson strikes a balance between complexity and engagement. It serves as a powerful tool to solidify genetics concepts, leaving a lasting impact on students' grasp of advanced genetic studies.
Elevate Genetic Understanding: Download this comprehensive lesson now to provide your students with a dynamic opportunity to explore genetic diseases, unravel mutations, and connect genetic structure to real-world health outcomes. Watch as their understanding of advanced genetic concepts reaches new heights!
Grade & Course Recommendation:
Middle School: Grade 8 Advanced Life Science, during heredity or molecular biology units.
High School: Grade 9–10 Biology, as a capstone for gene expression and mutations.
Cross-Curricular Connections:
Math Integration: Students interpret codon charts and calculate ratios of correct vs. mutated sequences.
ELA Integration: Students construct written explanations of cause and effect in genetic processes.
Health Science Integration: Ties to disorders resulting from frame-shift or point mutations.
Daily slide + literacy - based exit ticket included with purchase
Join the Lesson Laboratory and Teach for Tomorrow!
NGSS (Next Generation Science Standards)
High School NGSS Alignment
HS-LS1-1: Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.
Connection: Students analyze examples of how mutations alter DNA sequences and disrupt protein structure and function.HS-LS3-1: Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.
Connection: Students link specific mutations to phenotypic changes such as cystic fibrosis, Tay-Sachs disease, or sickle cell anemia.HS-LS3-2: Make and defend a claim based on evidence that inheritable genetic variations may result from new genetic combinations through meiosis, errors during replication, and/or mutations caused by environmental factors.
Connection: Students examine how different types of mutations—point, frameshift, insertion, deletion, and inversion—produce variations in proteins and traits.
Science & Engineering Practices:
Analyzing and interpreting data
Constructing explanations and designing solutions
Obtaining, evaluating, and communicating information
Crosscutting Concepts:
Structure and function
Cause and effect
Systems and system models
Common Core Standards
Grades 9–12:
CCSS.ELA-LITERACY.RST.9-10.3 / RST.11-12.3: Follow precisely a complex multistep procedure when carrying out experiments, taking measurements, or performing technical tasks. (Students interpret DNA-to-protein examples and mutation mechanisms step-by-step.)
CCSS.ELA-LITERACY.RST.9-10.4 / RST.11-12.4: Determine the meaning of domain-specific words and phrases (e.g., frameshift, codon, inversion, translation).
CCSS.ELA-LITERACY.RST.9-10.7 / RST.11-12.7: Integrate quantitative or technical information expressed in words with a version expressed visually (DNA sequences, codon charts, diagrams).
CCSS.ELA-LITERACY.WHST.9-10.2: Write informative/explanatory texts, including scientific analyses and summaries. (Students explain how mutations lead to specific phenotypes.)