Student Choice Inquiry | Evidence Evaluation Matrix | Abiogenesis & Early Cell Energy.
This multi-day digital investigation guides students through the scientific reasoning behind one of biology’s most profound questions: how did life first arise from nonliving chemistry?
Rather than presenting a single explanation, this lesson immerses students in historical experiments, early Earth chemistry, and modern origin-of-life hypotheses. Students analyze evidence, evaluate competing claims, and defend conclusions using structured reasoning tools.
The investigation begins with the historical debate over spontaneous generation. Students analyze how early thinkers interpreted natural phenomena and examine the controlled experiments of Redi, Needham, and Pasteur. Through interactive tasks and prediction exercises, students evaluate how experimental design and evidence led to the rejection of spontaneous generation.
Students then transition to early Earth conditions and prebiotic chemistry, examining volcanic activity, atmospheric composition, meteorite bombardment, and hydrothermal vent environments. They analyze how these conditions may have contributed to the formation of organic molecules and primitive systems.
The lesson culminates in a structured, choice-based investigation. Students select one of two central origin-of-life questions:
How did early life first obtain energy?
How did early life first begin replicating and performing cellular reactions?
All students read a two-page scientific article, analyze hypothesis visuals, and complete an evidence evaluation matrix. They compare:
Heterotroph vs. Autotroph hypotheses
RNA World vs. Metabolism-First hypotheses
Students evaluate supporting evidence, identify limitations and unanswered questions, and defend a claim using structured reasoning.
The investigation concludes with reflection and application, reinforcing how scientists continue to test and refine explanations about life’s origins.
Analyzing historical scientific experiments
Evaluating controlled experimental design
Exploring early Earth chemistry and prebiotic conditions
Comparing competing scientific hypotheses
Identifying supporting and missing evidence
Constructing evidence-based explanations
Complete 28-slide digital investigation
Structured historical experiment analysis
Two scientific reading articles
Student-choice inquiry pathway
Evidence evaluation matrix
Teacher key and printable literacy-based exit ticket
This lesson is designed for upper-level biology courses and emphasizes scientific reasoning over memorization. Students do not simply learn what scientists believe — they analyze how scientists evaluate competing explanations when direct evidence is limited.
It is well-suited for honors biology, AP Biology preparation, or advanced evolution units where structured argumentation and evidence analysis are priorities.
To see a preview of this lesson, click here.
NGSS Alignment (High School):
none- aligns with SEPs and CCCs
Science & Engineering Practices (SEPs):
Analyzing and Interpreting Data
Constructing Explanations
Engaging in Argument from Evidence
Obtaining, Evaluating, and Communicating Information
Crosscutting Concepts (CCCs):
Cause and Effect
Systems and System Models
Stability and Change
Common Core (Literacy in Science):
CCSS.ELA-LITERACY.RST.9-10.2; CCSS.ELA-LITERACY.RST.9-10.9; CCSS.ELA-LITERACY.WHST.9-10.1
Bundle Upgrade Policy
This lesson is included in one or more bundles. To support flexible purchasing and long-term use of our curriculum, Lesson Laboratory offers a bundle upgrade policy.
If you purchase this lesson and decide at a later date that you would like to upgrade to a bundle, you may request a store credit equal to the total amount paid for duplicate items.
To request an upgrade credit, please email thelessonlaboratory@gmail.com and include:
Your username
The order numbers for both the original purchase(s) and the bundle
The names of the duplicate resources
Requests must be submitted within 30 days of the bundle purchase. Credits are issued as store credit for future Lesson Laboratory purchases and are not provided as cash refunds.
This policy applies only to purchases of resources that are later included in a Lesson Laboratory bundle and is limited to one adjustment per upgrade pathway.
Student Choice Inquiry | Evidence Evaluation Matrix | Abiogenesis & Early Cell Energy.
This multi-day digital investigation guides students through the scientific reasoning behind one of biology’s most profound questions: how did life first arise from nonliving chemistry?
Rather than presenting a single explanation, this lesson immerses students in historical experiments, early Earth chemistry, and modern origin-of-life hypotheses. Students analyze evidence, evaluate competing claims, and defend conclusions using structured reasoning tools.
The investigation begins with the historical debate over spontaneous generation. Students analyze how early thinkers interpreted natural phenomena and examine the controlled experiments of Redi, Needham, and Pasteur. Through interactive tasks and prediction exercises, students evaluate how experimental design and evidence led to the rejection of spontaneous generation.
Students then transition to early Earth conditions and prebiotic chemistry, examining volcanic activity, atmospheric composition, meteorite bombardment, and hydrothermal vent environments. They analyze how these conditions may have contributed to the formation of organic molecules and primitive systems.
The lesson culminates in a structured, choice-based investigation. Students select one of two central origin-of-life questions:
How did early life first obtain energy?
How did early life first begin replicating and performing cellular reactions?
All students read a two-page scientific article, analyze hypothesis visuals, and complete an evidence evaluation matrix. They compare:
Heterotroph vs. Autotroph hypotheses
RNA World vs. Metabolism-First hypotheses
Students evaluate supporting evidence, identify limitations and unanswered questions, and defend a claim using structured reasoning.
The investigation concludes with reflection and application, reinforcing how scientists continue to test and refine explanations about life’s origins.
Analyzing historical scientific experiments
Evaluating controlled experimental design
Exploring early Earth chemistry and prebiotic conditions
Comparing competing scientific hypotheses
Identifying supporting and missing evidence
Constructing evidence-based explanations
Complete 28-slide digital investigation
Structured historical experiment analysis
Two scientific reading articles
Student-choice inquiry pathway
Evidence evaluation matrix
Teacher key and printable literacy-based exit ticket
This lesson is designed for upper-level biology courses and emphasizes scientific reasoning over memorization. Students do not simply learn what scientists believe — they analyze how scientists evaluate competing explanations when direct evidence is limited.
It is well-suited for honors biology, AP Biology preparation, or advanced evolution units where structured argumentation and evidence analysis are priorities.
To see a preview of this lesson, click here.
NGSS Alignment (High School):
none- aligns with SEPs and CCCs
Science & Engineering Practices (SEPs):
Analyzing and Interpreting Data
Constructing Explanations
Engaging in Argument from Evidence
Obtaining, Evaluating, and Communicating Information
Crosscutting Concepts (CCCs):
Cause and Effect
Systems and System Models
Stability and Change
Common Core (Literacy in Science):
CCSS.ELA-LITERACY.RST.9-10.2; CCSS.ELA-LITERACY.RST.9-10.9; CCSS.ELA-LITERACY.WHST.9-10.1
Bundle Upgrade Policy
This lesson is included in one or more bundles. To support flexible purchasing and long-term use of our curriculum, Lesson Laboratory offers a bundle upgrade policy.
If you purchase this lesson and decide at a later date that you would like to upgrade to a bundle, you may request a store credit equal to the total amount paid for duplicate items.
To request an upgrade credit, please email thelessonlaboratory@gmail.com and include:
Your username
The order numbers for both the original purchase(s) and the bundle
The names of the duplicate resources
Requests must be submitted within 30 days of the bundle purchase. Credits are issued as store credit for future Lesson Laboratory purchases and are not provided as cash refunds.
This policy applies only to purchases of resources that are later included in a Lesson Laboratory bundle and is limited to one adjustment per upgrade pathway.
